How Is TYLENOL^® With Naproxen Different Than Aleve?

The biggest difference is active ingredients.

Aleve contains one active ingredient:

• Naproxen sodium

TYLENOL® with Naproxen contains two active ingredients:

• Acetaminophen

• Naproxen sodium

By combining two complementary pain relievers in a single dose, TYLENOL® with Naproxen delivers faster, stronger pain relief that lasts 12 hours compared to Aleve 220 mg. It combines the fast-acting relief of acetaminophen with the long-lasting power of naproxen sodium.

TYLENOL® with Naproxen is the first and only FDA-approved over-the-counter pain reliever that combines 650 mg of acetaminophen and 220 mg of naproxen sodium in a single fixed-dose. It is indicated for the temporary relief of minor aches and pain in adults and children 12 years and over and is available without a prescription. For children under 12, consult a healthcare provider.

TYLENOL® with Naproxen contains the following active ingredients in each dose:

• 650 mg acetaminophen

• 220 mg naproxen sodium

Following rigorous testing, clinical studies, and partnerships with HCPs, TYLENOL® with Naproxen is redefining what’s possible in the OTC pain category and in doctors’ offices, with a simplified multimodal pain management option that aims to help drive increased adherence and patient relief.

Acetaminophen and naproxen sodium work differently in the body. Acetaminophen is a pain reliever. Naproxen sodium is also a pain reliever and belongs to a class of medicines known as nonsteroidal anti-inflammatory drugs (NSAIDs). By combining both ingredients into a single dose, TYLENOL® with Naproxen provides a multimodal approach to pain relief while maintaining the convenience of one OTC product.

Yes. TYLENOL® with Naproxen is clinically proven to be more effective than Aleve 220 mg. Clinical studies demonstrated that the combination of acetaminophen and naproxen sodium provided greater pain relief than naproxen sodium alone while continuing to deliver relief for 12 hours.

TYLENOL® with Naproxen starts working in under 30 minutes. The combination pairs the fast-acting relief associated with acetaminophen with the long-lasting performance of naproxen sodium. This allows consumers to get relief quickly while continuing to experience relief for 12 hours.

TYLENOL® with Naproxen provides pain relief for 12 hours. By combining acetaminophen and naproxen sodium in a single FDA-approved dose, TYLENOL® with Naproxen provides both fast onset and long duration of relief.

Consumers should always read and follow the Drug Facts label.

Acetaminophen and naproxen sodium have different safety considerations:

• Taking too much acetaminophen may cause serious liver damage.^[1,5]

• NSAIDs can increase the risk of stomach bleeding in some individuals.^[2,3]

• NSAIDs, except aspirin, can increase the risk of heart attack, heart failure, and stroke.

• NSAIDs may not be appropriate for everyone.^[2,3]

If you have questions about pain relief options, medications you take, or whether a product is right for you, talk with your healthcare provider.